The station opened on 16 November 1863. Originally there was a turntable behind the second platform which was used during the building of the tunnel under Enniscorthy town but was also used afterwards due to heavy traffic on Market Day. There was once an engine shed opposite the present day goods shed, two water columns were at each end of the platforms and there was also a very long siding for loading cattle. There was also a number of sidings, A siding for O'Donahoes was behind the station building, a siding for Bussetts Bacon Factory which is now the site of the Enniscorthy Swimming Pool, A siding at the entrance of the tunnel for Roches and another siding that went under Barrack Street via a tunnel to Minch Norton. Outside Enniscorthy there was sidings for St. Johns Flour Mill and St. Johns Foundry and also a siding at the head shunt for Kavanaghs Cement.
Enniscorthy was also where the locomotive No. 17 "Wicklow" left with a Cattle Special to Dublin Harcourt Street but was unable to stop and ran through the end wall and fell into Hatch Street, though it was not a serious accident and only injured the Driver who remained at his post in the cab and a horse on Hatch Street, this became one of Ireland's famous rail accidents.