Deiodinase
| thyroxine 5'-deiodinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.97.1.10 | ||||||||
| CAS number | 70712-46-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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Deiodinase (or iodide peroxidase or "Monodeiodinase") is a peroxidase enzyme that is involved in the activation or deactivation of thyroid hormones.
Types
Types of deiodinases include:
| family | prosthetic group | genes |
|---|---|---|
| Iodothyronine deiodinase | selenium | DIO1, DIO2, DIO3 |
| Iodotyrosine deiodinase | flavin | IYD |
In general, T4 (thyroxine) is converted into T3 (triiodothyronine) or rT3 (reverse triiodothyronine) by the iodothyronine deiodinase enzyme in target cells.
Starvation response
In starvation, deiodinase (Deiodinase I specifically) is inhibited thus lowering basal metabolic rate. However, in the brain, heart, skeletal muscle and thyriod, this is not so as these organs need to maintain homeostasis (skeletal muscle through shivering can increase temperature). This is achieved by the latter organs expressing deiodinase II rather than Deodinase I as in most peripheral tissues.[citation needed]
External links
- Deiodinase at the US National Library of Medicine Medical Subject Headings (MeSH)
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