Conorfone
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| Systematic (IUPAC) name | |
| (5α,8β)-17-(Cyclopropylmethyl)-8-ethyl-3-methoxy-4,5-epoxymorphinan-6-one | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 72060-05-0 |
| ATC code | None |
| PubChem | CID 172964 |
| ChemSpider | 151049 |
| Chemical data | |
| Formula | C23H29NO3 |
| Mol. mass | 367.481 g/mol |
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Conorfone (INN; TR-5109), also known as conorphone and codorphone, as well as conorphone hydrochloride (USAN), is an opioid analgesic that was never marketed.[1] It is an analogue of hydrocodone substituted with an 8-ethyl group and an N-cyclopropylmethyl group. It acts as a mixed agonist-antagonist at the μ-opioid receptor, and is slightly more potent than codeine in analgesic effects but associated with somewhat greater side effects.[2]
References
- ^ F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 514. ISBN 978-0-412-46630-4. Retrieved 12 May 2012.
- ^ Dionne RA, Wirdezk PR, Butler DP, Fox PC (1984). "Comparison of conorphone, a mixed agonist-antagonist analgesic, to codeine for postoperative dental pain". Anesthesia Progress 31 (2): 77–81. PMC 2515536. PMID 6597688.
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