Chakragati mouse (ckr) is an insertional transgenic mouse mutant displaying hyperactive behaviour and circling. It is also deficient in prepulse inhibition, latent inhibition and has brain abnormalities such as lateral ventricular enlargement that are typical to endophenotypic models of schizophrenia, which make it useful in screening for antipsychotic drug candidates. The mouse is currently licensed by Chakra Biotech.
- Verma V, Tan CH, Ong WY, et al. (March 2008). "The chakragati mouse shows deficits in prepulse inhibition of acoustic startle and latent inhibition". Neurosci. Res. 60 (3): 281–8. doi:10.1016/j.neures.2007.11.007. PMID 18164085.
- Torres G, Meeder BA, Hallas BH et al. (2005). "Ventricular size mapping in a transgenic model of schizophrenia". Developmental Brain Research 154 (1): 35–44. doi:10.1016/j.devbrainres.2004.08.011. PMID 15617753.
- Dawe GS, Ratty AK (2007). "The chakragati mouse: A mouse model for rapid in vivo screening of antipsychotic drug candidates". Biotechnology Journal 2 (11): 1344–52. doi:10.1002/biot.200700145. PMID 17886239.
|This neuroscience article is a stub. You can help Wikipedia by expanding it.|
Read in another language
This page is available in 1 language