CLEC5A

C-type lectin domain family 5, member A

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2YHF

Identifiers

Symbols

CLEC5A; CLECSF5; MDL-1; MDL1

External IDs

OMIM: 604987 MGI: 1345151 HomoloGene: 8302 GeneCards: CLEC5A Gene

Gene Ontology
Molecular function	• viral receptor activity • binding • sugar binding
Cellular component	• plasma membrane • integral to plasma membrane • cell surface
Biological process	• osteoblast development • anti-apoptosis • cellular defense response • signal transduction • response to virus • interspecies interaction between organisms • innate immune response
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
141.63 – 141.65 Mb

Chr 6:
40.52 – 40.54 Mb

PubMed search

[1]

[2]

C-type lectin domain family 5 member A or CLEC5A, also known as C-type lectin superfamily member 5 (CLECSF5) and myeloid DAP12-associating lectin 1 (MDL1) is a C-type lectin that in humans is encoded by the CLEC5A gene.^[1]^[2] It appears to be a member of a significant myeloid lineage activating pathway.

References

^ "Entrez Gene: C-type lectin domain family 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23601.
^ Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL (August 1999). "Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9792–6. doi:10.1073/pnas.96.17.9792. PMC 22289. PMID 10449773. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22289.

Chen ST, Lin YL, Huang MT, et al. (2008). "CLEC5A is critical for dengue-virus-induced lethal disease.". Nature 453 (7195): 672–6. doi:10.1038/nature07013. PMID 18496526.
Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine.". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily.". Proteins 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Drickamer K (1999). "C-type lectin-like domains.". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
Watson AA, O'Callaghan CA (2010). "Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (Pt 1): 29–31. doi:10.1107/S1744309109047915. PMID 20057064.

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CLEC5A

References

Further reading

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