CDH10

Cadherin 10 is a protein that in humans is encoded by the CDH10 gene.

CDH10
Identifiers
Aliases	CDH10, cadherin 10
External IDs	OMIM: 604555 MGI: 107436 HomoloGene: 68530 GeneCards: CDH10
Gene location (Human) Chr. Chromosome 5 (human) Band 5p14.2-p14.1 Start 24,487,100 bp End 24,644,978 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 A2|15 8.2 cM Start 18,819,033 bp End 19,014,322 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus Brodmann area 46 orbitofrontal cortex superior frontal gyrus cerebellar hemisphere entorhinal cortex prefrontal cortex dorsolateral prefrontal cortex Brodmann area 9 Top expressed in barrel cortex prefrontal cortex Region I of hippocampus proper facial motor nucleus ventral tegmental area anterior horn of spinal cord primary motor cortex dorsal tegmental nucleus olfactory bulb habenula More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding metal ion binding cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component integral component of membrane plasma membrane membrane glutamatergic synapse GABA-ergic synapse integral component of presynaptic active zone membrane integral component of postsynaptic specialization membrane cell surface catenin complex Biological process cell adhesion adherens junction organization homophilic cell adhesion via plasma membrane adhesion molecules cell-cell adhesion cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1008 320873 Ensembl ENSG00000040731 ENSMUSG00000022321 UniProt Q9Y6N8 P70408 RefSeq (mRNA) NM_001190450 NM_006727 NM_001317222 NM_001317224 NM_001362460 NM_009865 NM_001316758 RefSeq (protein) NP_001304151 NP_001304153 NP_006718 NP_001349389 NP_001304153.1 NP_001303687 NP_033995 Location (UCSC) Chr 5: 24.49 – 24.64 Mb Chr 15: 18.82 – 19.01 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Clinical significance

An association with autism has been suggested.

See also

• Cadherin
• Heritability of autism

External links

• Human CDH10 genome location and CDH10 gene details page in the UCSC Genome Browser.

Further reading

• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2000). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
• Wang K, Zhang H, Ma D, et al. (2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders". Nature. 459 (7246): 528–33. Bibcode:2009Natur.459..528W. doi:10.1038/nature07999. PMC 2943511. PMID 19404256.
• Potkin SG, Guffanti G, Lakatos A, et al. (2009). "Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease". PLOS ONE. 4 (8): e6501. Bibcode:2009PLoSO...4.6501P. doi:10.1371/journal.pone.0006501. PMC 2719581. PMID 19668339.
• Gil OD, Needleman L, Huntley GW (2002). "Developmental patterns of cadherin expression and localization in relation to compartmentalized thalamocortical terminations in rat barrel cortex". J. Comp. Neurol. 453 (4): 372–88. doi:10.1002/cne.10424. PMID 12389209. S2CID 25610258.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kools P, Vanhalst K, Van den Eynde E, van Roy F (1999). "The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14". FEBS Lett. 452 (3): 328–34. doi:10.1016/S0014-5793(99)00672-9. PMID 10386616. S2CID 44714251.
• Hillier LD, Lennon G, Becker M, et al. (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Ali J, Liao F, Martens E, Muller WA (1997). "Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion". Microcirculation. 4 (2): 267–77. doi:10.3109/10739689709146790. PMID 9219219. S2CID 21501093.
• Ma D, Salyakina D, Jaworski JM, et al. (2009). "A genome-wide association study of autism reveals a common novel risk locus at 5p14.1". Ann. Hum. Genet. 73 (Pt 3): 263–73. doi:10.1111/j.1469-1809.2009.00523.x. PMC 2918410. PMID 19456320.
• Hülsken J, Birchmeier W, Behrens J (1994). "E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton". J. Cell Biol. 127 (6 Pt 2): 2061–9. doi:10.1083/jcb.127.6.2061. PMC 2120290. PMID 7806582.