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Boca Grande Key is an island in the Florida Keys in Monroe County, Florida, United States. It is within the boundaries of the Key West National Wildlife Refuge. It is 183 acres (74 ha) in size.
 1859 U.S. Coast Survey Map or Nautical Chart of the Florida Keys and Key West with Boca Grande Key | |
  Boca Grande Key Boca Grande Key  Boca Grande Key Boca Grande Key (Caribbean) | |
| Geography | |
|---|---|
| Location | Gulf of Mexico |
| Coordinates | 24°32′04″N 82°00′18″W / 24.534556°N 82.005083°W |
| Archipelago | Florida Keys |
| Adjacent to | Florida Straits |
| Administration | |
| State | Florida |
| County | Monroe |
Located in the Outlying Islands of the Florida Keys, it is the largest and westernmost of the Mule Keys that are 9 miles (15 km) west of Key West.[1]