Big Six or Big 6 may refer to:

Art, entertainment, and media edit

Business and industry edit

Organizations and movements edit

  • Big Six (activists), leaders of major organizations in the civil rights movement within the United States in the 1960s
  • The Big Six (Ghana), six Ghanaian nationalists jailed by the British colonial government in 1948

Sports edit

Athletes edit

  • Big Six, the nickname for Jason Estrada, professional boxer born 1980
  • Big Six, the nickname for Christy Mathewson, a baseball pitcher from 1900 to 1916

Transportation edit

See also edit