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- Shanthi Suganya
- Abhirami Brinda Das
- RK Delhi Kumar
- Charulatha Sri Priya
- Karthik (Shanthi’s husband) Kamalesh
- Madhan (Abhirami’s husband) Satish
- Asst Commissioner Durai Saakshi Sivaa
- Priya Vanaja
- Arjun (RK’s son-in-law) Sanjay
- Anitha Arjun(RK’s daughter) Vanthana
- Indhu (Shanthi’s daughter) Baby Indra
- Rajeswari (RK’s wife) Jahnvi
- Joint Commissioner Vincent Retired Assistant Commissioner Afsar Babu
- Shyam (Abhirami’s brother) Venkat
- Jamuna Lakshmi
- Ramya (Abhirami’s sister) Aishwarya
- Srini (Ramya’s father-in-law Mohan V. Ram
- Director: Cheyar Ravie, Nithyanandam, Viduthalai
Anandham is a family drama with elements of business rivalry, romance, murders and other intrigues typical of Tamil soaps interwoven into it. However, unlike the stereotypical Tamil tear-jerker, Anandham depicts successful, independent-minded women rather than women battered by husbands and mothers-in-law.
The patriarch of the family – Radhakrishnan or RK – is an eminent industrialist whose blissful existence is threatened by a series of events involving his four children. Much of the first part of the serial revolved around two of RK’s daughters-in-law. Shanthi, a widow with a child and married to RK’s second son, Karthik, is the quintessential do-gooder in the serial but much of her early days were consumed by her struggle for acceptance within the family.
Shanthi’s tribulations were multiplied by the other daughter-in-law in the family, Abhirami, who had hoped that Karthik would marry her younger sister. Actress Brinda Das, who plays Abirami, turns in a superb performance as the arch villain. Abhirami had married into the RK family primarily to seek revenge on behalf of her late father, who had led her to believe that he had been wronged by RK in business. Soon, Abhirami began to wreak havoc on the RK family, stripping it of its family home and wealth.
The tragedy of losing his family home sent RK into an ashram, where his character began to mellow. Subsequently, he reconciled with Shanthi and later accepted the remarriage of Madhan, who worked up the courage to dissolve his enforced marriage to Abhirami and return to his first love, Rohini.
A little more than a year into the serial, Abhirami, increasingly estranged from her more righteous brother and sister, discovered that she was an adopted child. A good part of the serial since that discovery involved Abhirami and her real parents trying to determine the identity of one another. Abhirami’s real parents were separated from the time she was a baby. Her mother, Muthulakshmi, had left her father, the shady businessman Snakarapandian, after discovering that he had murdered someone for business gain. Muthulakshi lost her child while trying to save herself from pursuers sent by her husband and subsequently moved to Malaysia. She has now returned in a new avatar as the business magnate Charulatha. A year on, Abhirami has reunited with her father. But her mother, who had long been yearning to be reunited with her daughter, now steadfastly refuses to accept a devious daughter.
In the latest phase of the serial, which has since been extended beyond its originally scheduled end date, the focus is again on the gathering storm in the lives of the RK family. Madhan cannot come to terms with the fact that his wife Rohini chose to pursue her ambition of becoming a bank manager and accepting a transfer to Tirupathi while his mother was lying comatose. Rohini’s inability to return to Chennai in time for her mother-in-law’s funeral added further distance between husband and wife. Rohini has since relocated back to Chennai, fearing Sankarapandian’s efforts to reunite his daughter Abhirami with her former husband.
Meanwhile, two new characters have been introduced, Manisha, the former girl-friend of Karthik while he was on army duty in Kashmir, and Rocky, their son born out of wedlock and now living in an orphanage in Chennai and closely cared for by his aunt, Karthik’s sister Anitha.
As in every long-running serial, there are many sub-plots and supporting characters in this serial. But the sub-plot that stands out and led to a spike in the serial's popularity ratings involves a romance revolving around the character of Assistant Commissioner Durai, popularly known as A C Durai by the huge fan following that the hunk Saakshi Sivaa  has garnered through the role. Durai is a conscientious police officer whose blind devotion to duty cost him the affections of his girl-friend Priya, who was subsequently adopted by the RK household, allowing for the seamless switch from the main story to the sub-plot. After about half a year of estrangement, the couple reunited and were set to tie the knot when jealousy set in—Priya misinterpreted Durai’s relationship with an undercover police officer, Jamuna, masquerading as Sangkarapandian’s long-lost daughter. Durai then decided to put the marriage in abeyance until Priya gained sufficient trust in him. In the latest twist in the romance, Priya tries to demonstrate her maturity through self-sacrifice. She tries to persuade Durai to marry Jamuna, whose husband-to-be was killed by a vengeful Sankarapandian on the day of their intended marriage.
The serial is projected to run at least till the end of the year[when?] and many viewers are yearning for "anandham" through a happy ending in the saga of A. C. Durai's love life.