ACYP1

ACYP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K7J, 2K7K, 2VH7, 2W4C, 2W4P, 3TOQ
Identifiers
Aliases	ACYP1, ACYPE, acylphosphatase 1
External IDs	OMIM: 600875 MGI: 1913454 HomoloGene: 11932 GeneCards: ACYP1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	75,069,483 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	85,335,212 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lung; ; ganglionic eminence; ; pituitary gland; ; middle temporal gyrus; ; anterior pituitary; ; Brodmann area 9; ; right lobe of thyroid gland; ; Brodmann area 23; ; left lobe of thyroid gland;
	Top expressed in
	seminiferous tubule; ; spermatocyte; ; spermatid; ; facial motor nucleus; ; intercostal muscle; ; cerebellar vermis; ; medulla oblongata; ; medial vestibular nucleus; ; lateral geniculate nucleus; ; pontine nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; acylphosphatase activity;
Cellular component	extracellular exosome;
Biological process	phosphate-containing compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	97
	66204
	ENSG00000119640
	ENSMUSG00000008822
	P07311
	P56376
	NM_001107; NM_001302616; NM_001302617; NM_203488
	NM_025421; NM_001364360; NM_001364361
	NP_001098; NP_001289545; NP_001289546
	NP_079697; NP_001351289; NP_001351290
	Wikidata
View/Edit Human	View/Edit Mouse

Acylphosphatase-1 is an enzyme that in humans is encoded by the ACYP1 gene.^[5]^[6]^[7]

Function edit

Acylphosphatase is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of their tissue localization. This gene encodes the erythrocyte acylphosphatase isoenzyme. Alternatively spliced transcript variants that encode different proteins were identified through data analysis.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119640 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008822 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fiaschi T, Raugei G, Marzocchini R, Chiarugi P, Cirri P, Ramponi G (Jun 1995). "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase". FEBS Letters. 367 (2): 145–8. doi:10.1016/0014-5793(95)00553-L. PMID 7796909. S2CID 43318853.
^ Fiaschi T, Marzella R, Veggi D, Marzocchini R, Raugei G, Rocchi M, Ramponi G (Oct 1998). "Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3". Cytogenetics and Cell Genetics. 81 (3–4): 235–6. doi:10.1159/000015037. PMID 9730610. S2CID 46797997.
^ ^a ^b "Entrez Gene: ACYP1 acylphosphatase 1, erythrocyte (common) type".

External links edit

Human ACYP1 genome location and ACYP1 gene details page in the UCSC Genome Browser.

Further reading edit

Nassi P, Nediani C, Liguri G, Taddei N, Ramponi G (Jun 1991). "Effects of acylphosphatase on the activity of erythrocyte membrane Ca2+ pump". The Journal of Biological Chemistry. 266 (17): 10867–71. doi:10.1016/S0021-9258(18)99099-X. PMID 1645713.
Degl'Innocenti D, Berti A, Stefani M, Liguri G, Ramponi G (Aug 1990). "Immunoaffinity purification and immunoassay determination of human erythrocyte acylphosphatase". Biotechnology and Applied Biochemistry. 12 (4): 450–9. doi:10.1111/j.1470-8744.1990.tb00112.x. PMID 2169259. S2CID 26999394.
Liguri G, Camici G, Manao G, Cappugi G, Nassi P, Modesti A, Ramponi G (Dec 1986). "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure". Biochemistry. 25 (24): 8089–94. doi:10.1021/bi00372a044. PMID 3026468.
Paoli P, Pazzagli L, Giannoni E, Caselli A, Manao G, Camici G, Ramponi G (Jan 2003). "A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase" (PDF). The Journal of Biological Chemistry. 278 (1): 194–9. doi:10.1074/jbc.M206918200. PMID 12409302.
Degl'Innocenti D, Marzocchini R, Malentacchi F, Ramazzotti M, Raugei G, Ramponi G (Jan 2004). "ACYP1 gene possesses two alternative splicing forms that induce apoptosis". IUBMB Life. 56 (1): 29–33. doi:10.1080/15216540310001654349. PMID 14992377.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119640 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008822 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7796909-5] Fiaschi T, Raugei G, Marzocchini R, Chiarugi P, Cirri P, Ramponi G (Jun 1995). "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase". FEBS Letters. 367 (2): 145–8. doi:10.1016/0014-5793(95)00553-L. PMID 7796909. S2CID 43318853.

[pmid9730610-6] Fiaschi T, Marzella R, Veggi D, Marzocchini R, Raugei G, Rocchi M, Ramponi G (Oct 1998). "Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3". Cytogenetics and Cell Genetics. 81 (3–4): 235–6. doi:10.1159/000015037. PMID 9730610. S2CID 46797997.

[entrez-7] "Entrez Gene: ACYP1 acylphosphatase 1, erythrocyte (common) type".

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