Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men.[1]: 625 [2]
| Spindle cell lipoma | |
|---|---|
 | |
| Photomicrograph of a spindle cell lipoma. | |
| Specialty | Dermatology |
Signs and symptoms edit
Spindle cell lipoma is most frequently located in the upper back, shoulder, or posterior neck subcutaneous layer.[3] Nonetheless, reports of it occurring in the mediastinum, hypopharynx, larynx, anterior neck, suprasellar region, esophagus, nasal vestibule, tongue, floor of mouth, vallecula, parotid gland, and breast have been made.[4] The tumor is said to have an average diameter of 4 to 5 cm and is growing slowly. Usually, the tumor is painless and solitary.[3] There have been documented rare instances of numerous lesions, including family occurrences.[5]
Causes edit
The exact cause of spindle cell lipoma is unknown.[3]
Diagnosis edit
The diagnosis of spindle cell lipoma is mainly made in conjunction with clinical presentation and after other malignant tumors have been ruled out using cytologic, histologic, and cytogenetic evidence.[6]
According to histology, the lesion is made up of tiny, homogeneous spindle cells and mature adipocytes combined with eosinophilic collagen bundles inside a myxoidstroma. According to immunohistochemical staining, the spindle cells are positive for CD34 but negative for S-100 protein.[3]
See also edit
References edit
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
- ^ a b c d Seo, Bommie Florence; Kang, In Sook; Oh, Deuk Young (2014). "Spindle Cell Lipoma: A Rare, Misunderstood Entity". Archives of Craniofacial Surgery. 15 (2). Korean Cleft Palate-Craniofacial Association: 102–104. doi:10.7181/acfs.2014.15.2.102. ISSN 2287-1152. PMC 5556811. PMID 28913200.
- ^ D'Antonio, Antonio; Mottola, Giampiero; Caleo, Alessia; Addesso, Maria; Boscaino, Amedeo (2013). "Spindle Cell Lipoma of the Larynx". Ear, Nose & Throat Journal. 92 (6). SAGE Publications: E9–E11. doi:10.1177/014556131309200613. ISSN 0145-5613. PMID 23780614.
- ^ Fanburg-Smith, Julie C.; Devaney, Kenneth O.; Miettinen, Markku; Weiss, Sharon W. (1998). "Multiple Spindle Cell Lipomas". The American Journal of Surgical Pathology. 22 (1). Ovid Technologies (Wolters Kluwer Health): 40–48. doi:10.1097/00000478-199801000-00005. ISSN 0147-5185. PMID 9422314.
- ^ Machol, Jacques A.; Cusic, Jenna G.; OʼConnor, Elizabeth A.; Sanger, James R.; Matloub, Hani S. (2015). "Spindle Cell Lipoma of the Neck". Plastic and Reconstructive Surgery — Global Open. 3 (11). Ovid Technologies (Wolters Kluwer Health): e550. doi:10.1097/gox.0000000000000405. ISSN 2169-7574. PMC 4727702. PMID 26893975.
Further reading edit
- Meyer, Anders (2022). "The broadening spectrum of spindle cell lipoma and related tumors: A review". Human Pathology Reports. 28. Elsevier BV: 300646. doi:10.1016/j.hpr.2022.300646. ISSN 2772-736X.
- Ko, Jennifer S.; Daniels, Brianne; Emanuel, Patrick O.; Elson, Paul; Khachaturov, Vadim; McKenney, Jesse K.; Goldblum, John R.; Billings, Steven D. (2017). "Spindle Cell Lipomas in Women: A Report of 53 Cases". American Journal of Surgical Pathology. 41 (9): 1267–1274. doi:10.1097/PAS.0000000000000915. ISSN 0147-5185. PMID 28719462.